Delta Cure Poster

P60

Precision-cut liver slices as a model for evaluating therapeutic agents against HBV and HDV

M. Michelet, A. Roca Suarez, M. Plissonnier, A. Dubois, A. Diederichs, S. Heintz, M. Saez-Palma, M. Ben Abu, X. Grand, A. Favre, A. Chédotal, N. Van Renne, S. Fletcher, F. Mithieux, P. Bonnot, A. Dupré, N. Mouton, M. Rivoire, S. Phillips, E. Palma, S. Cho

P61

Interferon Response and Cell Division–Mediated Spread of Patient-Derived Hepatitis D Virus Strains

GE. Gnouamozi, J. Ringlander JB. Stenbäck, L. Mellert, F. Donati, S. Nkongolo, S. Urban

P62

A novel in vitro hepatocyte model of chronic propagative Hepatitis Delta Virus infection for long-term antiviral evaluation and host factor discovery

F. Bernardin, F. Pastor, C. Pons, R. Fouillé, O. Diaz, F. Habersetzer, TF. Baumert, ER. Verrier, D. Durantel and J. Lucifora

P63

A new humanized mouse model demonstrates HBV DNA integration-driven HDV spread mimicking chronic hepatitis D

C. Hingst, M. Schäfer, T. Volz, A. Volmari, K. Riecken, L. Bitar, M. Lütgehetmann, M. Zimmermann, B. Fehse, M. Dandri, L. Allweiss

P64

Kinetics of HBcrAg during Bulevirtide monotherapy in patients with HDV-related cirrhosis: a single-center real-world study

E. Degasperi, F. Facchetti, D. Sambarino, C. Scholtes, B. Testoni, S. Uceda Renteria, MP. Anolli, C. Charre, ML. Plissonnier, R. Perbellini, A. Callegaro, M. Levrero, F. Zoulim, P. Lampertico

P65

Host immunogenetics and first sequencing-based characterization of HDV in Uzbekistan

E. Kazakova, E. Musabaev, Z. Ismailova, M. Khodjaeva

P66

Association of IL28B gene polymorphisms rs8099917 and rs12979860 with progression of chronic hepatitis D

D. Abdurakhimova, N. Ibadullaeva, A. Khikmatullaeva, N. Kan

P67

One protein, many roles: Large HDAg controls viral assembly, replication and cytopathic effects to sustain viral persistence

B. Zehnder, J. Bauer, Y. Ni, Z. Zhang, A. Beer, A. Prawira, S. Urban

P68

Cell proliferation reduces innate antiviral defenses and promotes HDV spread in primary human hepatocytes in vivo

A. Volmari, T. Volz, J. Chen, L. Allweiss, M. Lütgehetmann, S. Fletcher, M. Holdorf, M. Dandri

P69

Pre-treatment and on-treatment markers of HBV cccDNA transcription predict virological response in chronic hepatitis D treated patients with pegylated-interferon or Bulevirtide

I. Carey, Z. Cargill, M. Anderson, J. Lok, T. Fortney, G. Cloherty, G. Dusheiko, K. Agarwal

P70

Comparative Laboratory Evaluation of the RoboGene HDV RNA Quantification Kit 2.0 for Quantitative Detection of Hepatitis D Virus RNA

LZ. Alieva, EA. Joldasova, NG. Kan, DT. Suyarkulova, RH. Juraev, EI. Musabaev

P71

Hepatitis-B core-related antigen (HBcrAg), phosphorylated HBcAg , and HBsAg isoforms as biomarkers of viral activity in chronic HDV infection: Do they mirror HDV RNA status?

I. Carey, Z. Cargill, M. Anderson, R. Geissler, T. Fortney, J. Lok, G. Cloherty, G. Dusheiko, K, Agarwal

P72

Clinical and virological characteristics of patients with low HDV RNA: HBV transcriptional activity persists despite minimal replication

I. Carey, Z. Cargill, M. Anderson, J. Lok, T. Fortney, R. Geissler, G. Cloherty, G. Dusheiko, K. Agarwal

P73

Paired liver and serum deep sequencing reveals differences between circulating HDV and intrahepatic viral populations

J. Ringlander, JB. Stenbäck, M. Andersson, G. Rydell, M. Lindh, M. Kann

P74

Discordance between two peripheral biomarkers of cccDNA transcriptional activity, namely HBV core related antigen and HBV RNA, in HBV-HDV co-infection.

J. Lok, M. Anderson, T. Fortney, Z. Cargill, G. Cloherty, J. McKeating, G. Dusheiko, K. Agarwal, I. Carey

P75

Health care resource utilisation and costs by disease state in adults with hepatitis delta virus in the United States

R. Wong, R. Gish, S. Dhuliawala, G. Leung, J. Lim, M. Rock, C. Kim

P76

Treatment of hbv-hdv hepatitis in a solid organ transplant recipient patient: a case report

E. Gabrielli, C. Valeriani

P77

Phylogeography and epidemiological history of hepatitis delta virus genotype 3 in South America

L. Honorato, M. Gouvea, W. Braga, A. da Costa, M. Rodgers, M. Berg, C. Silveira, E. Kallas, M. Thomazella, A. de Paula, M. Castilho, Y. Rodrigues, H. Paião, M. de Freitas, L. Ribeiro, D. Dall’Acqua, J. Queiroz, J. Salcedo, T. Dantas, R. Barboza, T. Tozett

P78

Phylogeographic reconstruction reveals recent African–Atlantic dispersal of hepatitis delta virus genotype 8

L. Honorato, K. Fassihi, S. Witkin, C. Mendes-Correa